Further Studies Should Help Elucidate The Potential Role Of Active ATF6 In Immune Cell Tumors And Other Cancers

Health, Medicine.

Atf6 and er stress: potential cancer biomarker? - atf6 is a constitutively expressed, endoplasmic reticulum( er) membrane - anchored transcription factor and is a key transcriptional activator of the unfolded protein response( reviewed in shen and prywes, and groenendyk and michalak) . Alzheimer' s) , Charcot - Marie Tooth Disease, and cancer, Cystic Fibrosis. More> > Active ATF6 is implicated in a number of disease states including myocardial infarction, neurodegenerative diseases, atherosclerosis( i. e.

The significance of over - expression of active( nuclear) ATF6 in a subset of immune system cancers remains to be elucidated. - research may also demonstrate the utility of atf6 as a novel biomarker for disease, or as part of a panel of antibodies that could be employed to discover and validate new protein biomarkers. Further studies should help elucidate the potential role of active ATF6 in immune cell tumors and other cancers. IMGENEX offers a number of related research tools for your ER, disease, cancer, and apoptosis studies.